Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.
Identifieur interne : 000C45 ( Main/Exploration ); précédent : 000C44; suivant : 000C46Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.
Auteurs : Ana Gomes [Portugal] ; Ricardo Ferraz [Portugal] ; Lauren Ficker [États-Unis] ; Margaret S. Collins [États-Unis] ; Cristina Prudêncio [Portugal] ; Melanie T. Cushion [États-Unis] ; Cátia Teixeira [Portugal] ; Paula Gomes [Portugal]Source :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antipaludiques, Chloroquine.
- traitement médicamenteux : Pneumonie à Pneumocystis.
- Cellules A549, Humains, Lignée cellulaire tumorale, Pneumocystis carinii, Sujet immunodéprimé.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antimalarials, Chloroquine.
- drug effects : Immunocompromised Host, Pneumocystis carinii.
- drug therapy : Pneumonia, Pneumocystis.
- A549 Cells, Cell Line, Tumor, Humans.
Abstract
The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
DOI: 10.1128/AAC.00983-18
PubMed: 30201816
Affiliations:
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Cushion</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Teixeira, Catia" sort="Teixeira, Catia" uniqKey="Teixeira C" first="Cátia" last="Teixeira">Cátia Teixeira</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal pgomes@fc.up.pt.</nlm:affiliation><country wicri:rule="url">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antimicrobial agents and chemotherapy</title><idno type="eISSN">1098-6596</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term><term>Antimalarials (pharmacology)</term><term>Cell Line, Tumor</term><term>Chloroquine (pharmacology)</term><term>Humans</term><term>Immunocompromised Host (drug effects)</term><term>Pneumocystis carinii (drug effects)</term><term>Pneumonia, Pneumocystis (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antipaludiques (pharmacologie)</term><term>Cellules A549</term><term>Chloroquine (pharmacologie)</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Pneumocystis carinii ()</term><term>Pneumonie à Pneumocystis (traitement médicamenteux)</term><term>Sujet immunodéprimé ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunocompromised Host</term><term>Pneumocystis carinii</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pneumonia, Pneumocystis</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Pneumonie à Pneumocystis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Cell Line, Tumor</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules A549</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Pneumocystis carinii</term><term>Sujet immunodéprimé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of <i>Pneumocystis</i> pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both <i>in vitro</i> and <i>in vivo</i>, we now report the potent action of these compounds on <i>Pneumocystis carinii in vitro</i> Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.</div></front></TEI><affiliations><list><country><li>Portugal</li><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="Portugal"><noRegion><name sortKey="Gomes, Ana" sort="Gomes, Ana" uniqKey="Gomes A" first="Ana" last="Gomes">Ana Gomes</name></noRegion><name sortKey="Ferraz, Ricardo" sort="Ferraz, Ricardo" uniqKey="Ferraz R" first="Ricardo" last="Ferraz">Ricardo Ferraz</name><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><name sortKey="Prudencio, Cristina" sort="Prudencio, Cristina" uniqKey="Prudencio C" first="Cristina" last="Prudêncio">Cristina Prudêncio</name><name sortKey="Teixeira, Catia" sort="Teixeira, Catia" uniqKey="Teixeira C" first="Cátia" last="Teixeira">Cátia Teixeira</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Ficker, Lauren" sort="Ficker, Lauren" uniqKey="Ficker L" first="Lauren" last="Ficker">Lauren Ficker</name></region><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S" last="Collins">Margaret S. Collins</name><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T" last="Cushion">Melanie T. Cushion</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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